Evaluation of resveratrol derivatives as potential antioxidants and identification of a reaction product of resveratrol and 2, 2-diphenyl-1-picryhydrazyl radical.
Journal of agricultural and food chemistry
confidence
Key findings
Synthetic polyhydroxystilbenes showed antioxidant activity; three derivatives more active than resveratrol; resveratrol dimer identified as DPPH reaction product.
View source on PubMed (PMID 10552752) ↗
- Sample size
- Not applicable
- Population
- Not applicable (in vitro chemical/analytical study)
- Dosing
- Not reported
- Duration
- Not reported
- Route
- Not applicable (in vitro)
- Blinding
- not_reported
- Controls
- none
- Drug class
- polyphenol
Full abstract
Resveratrol (3,4',5-trihydroxy-trans-stilbene), an antioxidant from grapes, and five other polyhydroxystilbenes were synthesized. Their antioxidative properties were evaluated in two model systems [pure lipid oxidation using the Rancimat method and 2, 2-diphenyl-1-picryhydrazyl (DPPH) free radical scavenging model.] 3, 3',4,5'-Tetrahydroxystilbene, 3,3',4,5,5'-pentahydroxystilbene, and 3,4,4',5-tetrahydroxystilbene were found to be more active than resveratrol in both models. A dimer of resveratrol was identified as the major radical reaction product when resveratrol was reacted with DPPH radicals.