NAD+review2001
Pathophysiological relevance of mitochondria in NAD(+) metabolism.
FEBS letters
confidence
Key findings
Review discussing mitochondrial NAD+ metabolism, storage, and release mechanisms in physiological and pathological signaling; no clinical endpoints reported.
View source on PubMed (PMID 11248227) ↗
- Sample size
- Not reported
- Population
- Not applicable (review article)
- Dosing
- Not reported
- Duration
- Not reported
- Route
- Not reported
- Blinding
- not_reported
- Controls
- not_reported
- Drug class
- coenzyme
Full abstract
Pyridine nucleotides are mostly stored within mitochondria where they are involved in different functions ranging from energy metabolism to cellular signaling. Here we discuss the mechanisms of mitochondrial NAD(+) metabolism and release that may contribute to the crucial roles played by these organelles as triggers or amplifiers of physiological and pathological events.