Vitamin Cobservational2003
An improved methodology for the synthesis of enantiomerically pure (S)-2,3-O-cyclohexylideneglyceraldehyde.
Enantiomer
confidence
Key findings
Methods paper describing synthesis of (S)-2,3-O-cyclohexylideneglyceraldehyde from ascorbic acid; no clinical or biological endpoints.
View source on PubMed (PMID 12643315) ↗
- Sample size
- N/A
- Population
- N/A (synthetic chemistry methods paper)
- Dosing
- N/A
- Duration
- N/A
- Route
- N/A
- Blinding
- not_reported
- Controls
- none
- Drug class
- water-soluble vitamin
Full abstract
An improved methodology to prepare (S)2,3-O-cyclohexylideneglyceraldehyde is described. Starting from the commercially available (L)-cyclohexylidene protected ascorbic acid the enantiomerically pure aldehyde was synthesized in only two steps in 41% overall yield.