Curcuminobservational2004
Biomimetic oxidation of curcumin with hydrogen peroxide catalyzed by 5,10,15,20-tetraarylporphyrinatoiron(III) chlorides in dichloromethane.
Chemical & pharmaceutical bulletin
confidence
Key findings
Biomimetic oxidation of curcumin with H2O2 catalyzed by iron porphyrins yields a C-C coupled curcumin dimer (40-70%); structure confirmed by NMR/IR/MS.
View source on PubMed (PMID 14600390) ↗
- Sample size
- N/A
- Population
- N/A (in vitro chemistry study)
- Dosing
- N/A
- Duration
- N/A
- Route
- N/A
- Blinding
- not_reported
- Controls
- none
- Drug class
- polyphenol
Full abstract
The biomimetic oxidation of curcumin, a main turmeric pigment with hydrogen peroxide catalyzed by different 5,10,15,20-tetraarylporphyrinatoiron(III) chlorides [TAPFe(III)Cl] in dichloromethane has been studied to give a C-C coupled curcumin dimer in 40-70% yield. The structure of the dimer has been elucidated by (1)H-, (13)C-NMR, IR and FAB-Mass spectroscopic data.