NAD+animalAnimal model2005
Redefining neuroprotective gene therapeutic strategies: Lessons learned from caloric restriction and NAD(+) metabolism.
Journal of Alzheimer's disease : JAD
confidence
Key findings
Review/perspective article predicting neuroprotection via molecular genetic perturbations affecting nuclear NAD+ metabolism; no clinical/biological endpoints reported.
View source on PubMed (PMID 15665413) ↗
- Sample size
- N/A
- Population
- Not applicable (review/perspective article)
- Dosing
- N/A
- Duration
- N/A
- Route
- N/A
- Blinding
- not_reported
- Controls
- not_reported
- Drug class
- coenzyme
Full abstract
Herein a case is made for the development of novel cytoprotective approaches based upon molecular mechanisms thought to underlie the caloric restriction phenomenon. This analysis leads to the prediction that molecular genetic perturbations affecting the metabolism of nuclear NAD(+) and metabolites will be neuroprotective.