NAD+observational2005
Electrical communication between NAD-dependent enzyme and metal electrode using ferrocene-labeled NAD derivatives.
Journal of bioscience and bioengineering
confidence
Key findings
Synthesized Fc-NAD derivatives acted as electron-relay cofactors; oxidation current depended on ethanol addition and Fc spacer length. No clinical/biological endpoints.
View source on PubMed (PMID 16233579) ↗
- Population
- In vitro enzyme-electrode system
- Blinding
- not_reported
- Controls
- none
- Drug class
- coenzyme
Full abstract
The target N6-ferrocene substituted NAD derivatives (ferrocene-labeled NAD, Fc-NAD) were synthesized as an electron-relay NAD cofactor. The synthesized NAD derivatives possessed some biological activities as substrates in the alcohol dehydrogenase systems. The oxidation current depended on both addition of ethanol and spacer length of Fc-NAD.