NAD+observational2005
Crystallographic studies of Mycobacterium tuberculosis polyphosphate/ATP-NAD kinase complexed with NAD.
Journal of bioscience and bioengineering
confidence
Key findings
Crystallographic study of M. tuberculosis polyphosphate/ATP-NAD kinase complexed with NAD; crystal belongs to hexagonal space group P6(2)22.
View source on PubMed (PMID 16233726) ↗
- Population
- Mycobacterium tuberculosis (in vitro crystallography)
- Blinding
- not_reported
- Controls
- none
- Drug class
- coenzyme
Full abstract
NAD kinase from Mycobacterium tuberculosis (Ppnk) uses ATP or inorganic polyphosphate [poly(P)]. Ppnk overexpressed in Escherichia coli was purified and crystallized in the presence of NAD. Preliminary X-ray analysis of the resultant crystal indicate that the crystal belongs to hexagonal space group P6(2)22 and is holo-Ppnk complexed with NAD.