NAD+observational2005
The role of the carboxamide group in nicotinamide adenine dinucleotide in relation to hydride transfer: the reduced form of the dinucleotide as remedy in the modulation of neurotransmission.
Nucleosides, nucleotides & nucleic acids
confidence
Key findings
Review of stereochemical role of carboxamide group in NADH-NAD+ conversions; no clinical or biological endpoints reported.
View source on PubMed (PMID 16247970) ↗
- Sample size
- Not reported
- Population
- Not applicable (review/model systems)
- Dosing
- Not reported
- Duration
- Not reported
- Route
- Not reported
- Blinding
- not_reported
- Controls
- not_reported
- Drug class
- coenzyme
Full abstract
The stereochemical significance of the carboxamide group in combination with the ring nitrogen in NADH-NAD+ conversions has been demonstrated. This has been shown in model systems as well as under enzymatic conditions. The role of the carboxamide group in selective regiospecific interactions has been discussed for neurodegenerative diseases.