Hyaluronic Acid2007
F-16438s, novel binding inhibitors of CD44 and hyaluronic acid. II. Producing organism, fermentation, isolation, physico-chemical properties and structural elucidation.
The Journal of antibiotics
confidence
Key findings
Five novel CD44/hyaluronic acid binding inhibitors (F-16438 A, B, E, F, G) isolated from fungal strain Gloeoporus dichrous; structural elucidation reported.
View source on PubMed (PMID 17323644) ↗
- Sample size
- Not reported
- Population
- Not applicable (fungal strain isolation study)
- Dosing
- Not reported
- Duration
- Not reported
- Route
- Not reported
- Blinding
- not_reported
- Controls
- not_reported
- Drug class
- glycosaminoglycan
Full abstract
In the course of our screening for binding inhibitors of CD44 and hyaluronic acid, five active compounds, F-16438 A, B, E, F and G were found and isolated from the cultured broth of a fungal strain, Gloeoporus dichrous SANK 30502. The structures of these compounds except for F-16438 G were elucidated by physico-chemical and spectral data to be new compounds related to caloporoside; F-16438 G was identified to be the 6'-malonylated derivative of caloporoside.