Hyaluronic Acid1977
Conformation of hyaluronate in neutral and alkaline solutions.
Biochimica et biophysica acta
confidence
Key findings
pH increase to 12.5 caused reversible drop in viscosity and radius of gyration of hyaluronate; conformational change specific to hyaluronate.
View source on PubMed (PMID 18206) ↗
- Population
- In vitro hyaluronate solution
- Blinding
- not_reported
- Controls
- active_comparator
- Drug class
- glycosaminoglycan
Full abstract
Increasing the pH of a neutral salt solution of sodium hyaluronate to 12.5 produces a rapid drop in viscosity which is reversible upon restoring the pH to neutrality. Light scattering data showing a decrease in radius of gyration with no change in molecular weight and negative results with chondroitin and other acidic glycosaminoglycans suggest that the conformational change is specific for hyaluronate molecules.