Gonadorelin2012
Evolution of gonadotropin-releasing hormones.
Trends in endocrinology and metabolism: TEM
confidence
Key findings
Review of GnRH evolution and variant forms; no clinical or biological endpoints reported.
View source on PubMed (PMID 18407120) ↗
- Sample size
- N/A
- Population
- Not applicable (review of GnRH evolution)
- Dosing
- N/A
- Duration
- N/A
- Route
- N/A
- Blinding
- not_reported
- Controls
- not_reported
- Drug class
- GnRH analog
Full abstract
GnRH was originally isolated as a hypothalamic peptide hormone that regulates the reproductive system by stimulating the release of gonadotropins from the anterior pituitary. However, multiple molecular forms of the peptide have evolved, which have been coopted for a variety of regulatory functions: as a neurotransmitter in the central and sympathetic nervous systems, as a paracrine regulator in the gonads and placenta, and as an autocrine regulator in tumor cells. We review here the evolution of these variant forms of GnRH and their functions.