L-Tyrosineobservational2008
Synthesis of hydroxylated bicyclic amino acids from L-tyrosine: octahydro-1H-indole carboxylates.
The Journal of organic chemistry
confidence
Key findings
Synthetic chemistry method for stereoselective synthesis of polyhydroxylated L-Choi derivatives from L-tyrosine; no clinical/biological endpoints.
View source on PubMed (PMID 18767800) ↗
- Sample size
- Not reported
- Population
- Not applicable (synthetic chemistry study)
- Dosing
- Not reported
- Duration
- Not reported
- Route
- Not reported
- Blinding
- not_reported
- Controls
- not_reported
- Drug class
- amino acid
Full abstract
A stereoselective approach to polyhydroxylated L-Choi derivatives has been developed. The oxidative cyclization of L-tyrosine was optimized to avoid partial racemization and to allow a more efficient scale-up.