Bioproduction of resveratrol and stilbene derivatives by plant cells and microorganisms.
Trends in biotechnology
confidence
Key findings
Review of bioproduction methods for resveratrol/stilbene derivatives by plant cells and recombinant microorganisms; no clinical/biological endpoints reported.
View source on PubMed (PMID 19875185) ↗
- Sample size
- Not applicable
- Population
- Not applicable (review of bioproduction methods)
- Dosing
- Not applicable
- Duration
- Not applicable
- Route
- Not applicable
- Blinding
- not_reported
- Controls
- not_reported
- Drug class
- polyphenol
Full abstract
Trans-resveratrol is a phenolic plant compound that has been recognized for its benefits on human health. Currently, increasing demand for trans-resveratrol for nutraceutical, cosmetic, and putatively pharmaceutic uses makes its production from sustainable sourcing a necessity. In this context, the use of biotechnology through recombinant microorganisms and plant cell suspensions is particularly promising because it represents a reliable alternative method of trans-resveratrol production under controlled conditions. Tailoring yeast or bacteria with genes that encode enzymes of the trans-resveratrol pathway and further elicitation of plant-cell metabolism might represent powerful strategies for increased trans-resveratrol bioproduction. This review aims at describing and comparing these different available methods, with a focus on their respective advantages, limits and perspectives as a basis for scale-up in large culture volumes.