Higher-order assembly of collagen peptides into nano- and microscale materials.
Biochemistry
confidence
Key findings
Review of collagen peptide higher-order assembly into nano/microscale materials for biomaterials applications; no clinical/biological endpoints reported.
View source on PubMed (PMID 20415447) ↗
- Sample size
- N/A
- Population
- Not applicable (materials science review)
- Dosing
- N/A
- Duration
- N/A
- Route
- N/A
- Blinding
- not_reported
- Controls
- not_reported
- Drug class
- peptide
Full abstract
The triple-helical structure of collagen peptides has recently been harnessed as a subunit in the higher-order assembly of unique biomaterials. Specific assembly signals have been designed within collagen peptides, including hydrophobic groups, electrostatic interactions, and metal-ligand binding, to name a few. In this way, a range of novel assemblies have been obtained, including nano- to microscale fibers, gels, spheres, and meshes, each with the potential for novel biological applications in drug delivery, tissue engineering, and regenerative medicine.