NAD+observational2011

One-step, nonenzymatic synthesis of O-acetyl-ADP-ribose and analogues from NAD and carboxylates.

The Journal of organic chemistry

confidence

Key findings

One-step, nonenzymatic synthesis of O-acetyl-ADP-ribose and analogues from NAD and carboxylates in acetic acid.

Sample size: N/A
Population: N/A (chemical synthesis method)
Dosing: NAD and sodium acetate in acetic acid
Duration: N/A
Route: N/A
Blinding: not_reported
Controls: none
Drug class: coenzyme

Full abstract

O-Acetyl-ADP-ribose (OAADPR) is a metabolite produced from nicotinamide adenine dinucleotide (NAD) as a product of sirtuin-mediated protein deacetylation. We present here a simple, one-step, nonenzymatic synthesis of OAADPR from NAD and sodium acetate in acetic acid. We extended the reaction to other carboxylic acids, demonstrating that the reaction between NAD and nonaqueous carboxylate buffers produces mixtures of the corresponding 2'- and 3'-carboxylic esters.

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