NAD+observational2012
Old enzymes, new tricks: sirtuins are NAD(+)-dependent de-acylases.
Cell metabolism
confidence
Key findings
Review article on sirtuins as NAD+-dependent de-acylases; identifies new enzymatic activity for SIRT5; no clinical/biological endpoints reported.
View source on PubMed (PMID 22100408) ↗
- Sample size
- Not applicable
- Population
- Not applicable (review article)
- Dosing
- Not applicable
- Duration
- Not applicable
- Route
- Not applicable
- Blinding
- not_reported
- Controls
- not_reported
- Drug class
- coenzyme
Full abstract
Seven mammalian sirtuins are nicotinamide adenine dinucleotide (NAD)(+)-dependent deacetylases and are important modulators of energy metabolism and stress resistance. Two new studies by Du et al. (2011) and Peng et al. (2011) identify a new enzymatic activity for SIRT5, expanding the cellular repertoire of posttranslational modifications targeted by the sirtuins.