Compositional control of higher order assembly using synthetic collagen peptides.
Journal of the American Chemical Society
confidence
Key findings
Synthetic collagen peptides self-assemble via noncovalent electrostatic interactions into monomer, trimer, fiber, and hydrogel; stoichiometry/concentration control higher order assembly.
View source on PubMed (PMID 22171825) ↗
- Sample size
- N/A
- Population
- In vitro synthetic collagen peptide hydrogel study
- Dosing
- Varying stoichiometry and concentration of two-component collagen peptides
- Duration
- N/A
- Route
- In vitro
- Blinding
- not_reported
- Controls
- none
- Drug class
- peptide
Full abstract
We present the case of a two-component collagen peptide hydrogel that self-assembles through noncovalent electrostatic interactions. Natural collagen materials, such as those of connective tissue or the basement membrane, assemble in a hierarchic fashion. Similarly, the synthetic peptides presented here proceed from monomer to trimer to fiber and, finally, to a hydrogel. By varying stoichiometry and concentration, we are able to dissect the stages of higher order assembly. Insight gained from this study will improve the molecular design of biomimetic materials.