L-TyrosineanimalAnimal model2013
Preparation of 3-bromo-L-tyrosine and 3,5-dibromo-L-tyrosine.
Amino acids
confidence
Key findings
Chemical synthesis method for preparing 3-bromo-L-tyrosine and 3,5-dibromo-L-tyrosine from L-tyrosine; no clinical or biological endpoints reported.
View source on PubMed (PMID 22836678) ↗
- Sample size
- Not applicable
- Population
- Not applicable (chemical synthesis method)
- Dosing
- Not applicable
- Duration
- Not applicable
- Route
- Not applicable
- Blinding
- not_reported
- Controls
- none
- Drug class
- mitochondrial peptide
Full abstract
L-Tyrosine is converted to 3-bromo-L-tyrosine in good yield by reaction with 1.2 equiv. of DMSO in HBr/AcOH, while reaction with 2.2 equiv. of DMSO under comparable conditions results in formation of 3,5-dibromo-L-tyrosine in good yield. This is the simplest, safest and most efficient method for the preparation of gram quantities of either 3-bromo-L-tyrosine or 3,5-dibromo-L-tyrosine.