Mapping of different neuropeptides in the lower brainstem of the rat: with special reference to the ventral surface.
Journal of the autonomic nervous system
confidence
Key findings
Neuropeptide map of beta-endorphin, VIP, substance P, and somatostatin-like reactive neurons/fibers in rat lower brainstem; no clinical/biological endpoints reported.
View source on PubMed (PMID 2415571) ↗
- Sample size
- not_reported
- Population
- Rat lower brainstem (medulla oblongata)
- Dosing
- not_reported
- Duration
- not_reported
- Route
- not_reported
- Blinding
- not_reported
- Controls
- none
- Drug class
- neuropeptide
Full abstract
A neuropeptide map of beta-endorphin-, vasoactive intestinal peptide-, substance P-, and somatostatin-like reactive neurons and nerve fibers was made by means of immunohistochemistry. Indirect immunofluorescence was carried out in parallel to peroxidase-antiperoxidase reaction using a modified fixation technique. Special interest was directed to the superficial ventral regions of the medulla oblongata where regulative centers for respiration and circulation have been localized. The atlas presented offers a reliable tool for a precise neuromorphological localization of these neuropeptides in pharmacophysiological experiments.