[Importance of NAMPT-mediated NAD-biosynthesis and NAD-dependent deacetylase SIRT1 in the crosstalk between circadian rhythm and metabolism].
Nihon rinsho. Japanese journal of clinical medicine
confidence
Key findings
Review article on NAMPT-mediated NAD biosynthesis and SIRT1 in circadian-metabolism crosstalk; no clinical/biological endpoints reported.
View source on PubMed (PMID 24437277) ↗
- Sample size
- N/A
- Population
- Not applicable (review article)
- Dosing
- N/A
- Duration
- N/A
- Route
- N/A
- Blinding
- not_reported
- Controls
- not_reported
- Drug class
- coenzyme
Full abstract
Circadian rhythms are generated by well-conserved interlocked transcriptional feedback loops that involve clock genes. A growing body of research suggests that there is biological crosstalk between circadian rhythm and metabolism. We recently found that the key NAD biosynthetic enzyme, nicotinamide phosphoribosyltransferase (NAMPT), and NAD-dependent deacetylase SIRT1 play a critical role in such crosstalk, by creating a novel feedback loop in which NAD functions as a "metabolic oscillator". This review aims to summarize recent progress in elucidating the pathophysiological importance of clock genes, NAMPT-mediated NAD biosynthesis, and SIRT1, in the crosstalk between circadian rhythm and metabolism.