NAD+observational2014
Self-immolative bioluminogenic quinone luciferins for NAD(P)H assays and reducing capacity-based cell viability assays.
Chembiochem : a European journal of chemical biology
confidence
Key findings
Synthesis of self-cleavable trimethyl lock quinone-luciferin substrates for diaphorase to measure NAD(P)H and monitor viable cells; no clinical/biological endpoints reported.
View source on PubMed (PMID 24591148) ↗
- Sample size
- Not reported
- Population
- In vitro biological samples and viable cells
- Dosing
- Not reported
- Duration
- Not reported
- Route
- In vitro
- Blinding
- not_reported
- Controls
- not_reported
- Drug class
- coenzyme
Full abstract
Highly sensitive self-cleavable trimethyl lock quinone-luciferin substrates for diaphorase were designed and synthesized to measure NAD(P)H in biological samples and monitor viable cells via NAD(P)H-dependent cellular oxidoreductase enzymes and their NAD(P)H cofactors.