Collagen Peptidesobservational2015
Site-specific cross-linking of collagen peptides by lysyl advanced glycation endproducts.
Chemical communications (Cambridge, England)
confidence
Key findings
Synthetic lysyl AGE cross-linked collagen peptides used for biochemical studies (proteolysis, CD); no clinical/biological endpoints reported.
View source on PubMed (PMID 24705519) ↗
- Population
- In vitro (synthetic collagen peptides)
- Blinding
- not_reported
- Controls
- none
- Drug class
- peptide
Full abstract
Cross-linking of proteins by advanced glycation endproducts (AGEs) causes a host of pathological conditions but their exact roles are unknown. Cross-linking lysyl AGEs were synthesized and incorporated into two types of collagen peptides. The utility of these cross-linked peptides for biochemical investigations was demonstrated by proteolysis studies and circular dichroism.