NAD+observational2015
SnapShot: sirtuins, NAD, and aging.
Cell metabolism
confidence
Key findings
Review of sirtuins as NAD-dependent enzymes regulating aging and biological processes; no clinical/biological endpoints reported.
View source on PubMed (PMID 24988458) ↗
- Sample size
- N/A
- Population
- Not applicable (review article)
- Dosing
- N/A
- Duration
- N/A
- Route
- N/A
- Blinding
- not_reported
- Controls
- not_reported
- Drug class
- coenzyme
Full abstract
Sirtuins are highly conserved nicotinamide adenine dinucleotide (NAD)-dependent enzymes that regulate a wide range of biological processes, including aging, in several species. This SnapShot provides a comprehensive overview of the targets, enzymatic activities, and physiological functions of the seven mammalian sirtuins, as well as the regulation of the biosynthetic pathways regulating NAD availability.