NAD+review2016

ADP-ribosyltransferases and poly ADP-ribosylation.

Current protein & peptide science

confidence

Key findings

Review of ADP-ribosyltransferases and poly ADP-ribosylation; no clinical or biological endpoints reported.

Sample size: N/A
Population: Not applicable (review article)
Dosing: N/A
Duration: N/A
Route: N/A
Blinding: not_reported
Controls: not_reported
Drug class: coenzyme

Full abstract

Protein ADP-ribosylation is an important posttranslational modification that plays versatile roles in multiple biological processes. ADP-ribosylation is catalyzed by a group of enzymes known as ADP-ribosyltransferases (ARTs). Using nicotinamide adenine dinucleotide (NAD(+)) as the donor, ARTs covalently link single or multiple ADP-ribose moieties from NAD(+) to the substrates, forming mono ADP-ribosylation or poly ADP-ribosylation (PARylation). Novel functions of ARTs and ADPribosylation have been revealed over the past few years. Here we summarize the current knowledge on ARTs and PARylation.

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