Collagen Peptidesobservational2016
On resin synthesis and cross-linking of collagen peptides containing the advanced glycation end-product pyrraline via Maillard condensation.
Chemical communications (Cambridge, England)
confidence
Key findings
Synthesis of collagen peptides containing pyrraline and a novel pyrraline-derived cross-link via Maillard condensation on resin; no clinical/biological endpoints reported.
View source on PubMed (PMID 25963401) ↗
- Population
- In vitro (resin-bound peptide synthesis)
- Blinding
- not_reported
- Controls
- none
- Drug class
- peptide
Full abstract
Glycation and its products cause a host of pathological conditions but their exact roles are yet to be determined. Pyrraline, a key product of glycation, and a novel pyrraline-derived cross-link have been incorporated into collagenous peptides via Maillard condensations performed on resin-bound peptide sequences.