Dasatinibobservational2016
Translating the effects of mTOR on secretory senescence.
Nature cell biology
confidence
Key findings
Review article on mTOR's role in controlling senescence-associated secretory phenotype; no clinical or biological endpoints related to dasatinib reported.
View source on PubMed (PMID 26419801) ↗
- Sample size
- Not applicable
- Population
- Not specified (review article)
- Dosing
- Not applicable
- Duration
- Not applicable
- Route
- Not applicable
- Blinding
- not_reported
- Controls
- not_reported
- Drug class
- senolytic
Full abstract
Cellular senescence is often accompanied by the production of secreted proteins that mediate the diverse effects of senescence on the tissue microenvironment. The mammalian target of rapamycin (mTOR), a master regulator of protein synthesis, is now shown to control the senescence-associated secretory phenotype by modulating gene transcription and mRNA translation and stabilization.