IvermectinanimalAnimal model2017
Ivermectin to reduce malaria transmission II. Considerations regarding clinical development pathway.
Malaria journal
confidence
Key findings
Review paper on ivermectin as a complementary vector control tool for malaria; no clinical or biological endpoints reported.
View source on PubMed (PMID 28434405) ↗
- Sample size
- Not applicable
- Population
- Not specified (review of eco-epidemiological contexts for malaria transmission control)
- Dosing
- Not specified
- Duration
- Not applicable
- Route
- Not specified
- Blinding
- not_reported
- Controls
- none
- Drug class
- antiparasitic
Full abstract
The development of ivermectin as a complementary vector control tool will require good quality evidence. This paper reviews the different eco-epidemiological contexts in which mass drug administration with ivermectin could be useful. Potential scenarios and pharmacological strategies are compared in order to help guide trial design. The rationale for a particular timing of an ivermectin-based tool and some potentially useful outcome measures are suggested.