NAD+observational2019
Biomimetic Oxidation of Aldehyde with NAD+ Models: Glycolysis-Type Hydrogen Transfer in an NAD+ /NADH Model System.
Angewandte Chemie (International ed. in English)
confidence
Key findings
Biomimetic study of NAD+/NADH redox cycle in glycolysis-type hydrogen transfer; no clinical or biological endpoints reported.
View source on PubMed (PMID 29710893) ↗
- Population
- In vitro biochemical model system
- Blinding
- not_reported
- Controls
- not_reported
- Drug class
- coenzyme
Full abstract
Just like in biological systems, the GAPDH-catalyzed oxidation of aldehyde to carboxylate proceeds in conjunction with 1,4-selective reduction of NAD+ to NADH model compounds [Eq. (1)]. The combination of GAPDH- and LDH-type transfer reactions is also described here as a system mimic for the NAD+ /NADH redox cycle in anaerobic glycolysis. GAPDH=D-glyceraldehyde-3-phosphate dehydrogenase, LDH=L-lactate dehydrogenase.