Collagen Peptidesobservational2018
Variation in the Yaa position of collagen peptides containing azaGlycine.
Chemical communications (Cambridge, England)
confidence
Key findings
Investigated amino acid variation in Yaa position of collagen peptides with azaGlycine; demonstrated azaGlycine reliability and provided strategy for stabilizing triple helical assembly.
View source on PubMed (PMID 30288510) ↗
- Sample size
- Not reported
- Population
- Not applicable (in vitro peptide chemistry study)
- Dosing
- Not reported
- Duration
- Not reported
- Route
- Not reported
- Blinding
- not_reported
- Controls
- none
- Drug class
- peptide
Full abstract
Herein, we report the systematic investigation of amino acid variation in the Yaa position of collagen peptides containing an adjacent azaGlycine residue. We demonstrate the reliability of azaGlycine as a glycine replacement and provide a sequence independent strategy for stabilizing the triple helical assembly of collagen peptides.