NAD+observational2018
Reversible redox inter-conversion of biologically active NAD+/NADH derivatives bound to a gold electrode: ToF-SIMS evidence.
Chemical communications (Cambridge, England)
confidence
Key findings
Electrochemical reversible redox of NAD+/NADH derivatives achieved via gold electrode functionalization; characterized by ToF-SIMS.
View source on PubMed (PMID 30457615) ↗
- Population
- In vitro (gold electrode functionalization)
- Blinding
- not_reported
- Controls
- none
- Drug class
- coenzyme
Full abstract
The realization of the reversible inter-conversion between NADH and NAD+ is a long-term challenge in biological and energy-related chemistry. Here, we achieve the electrochemical reversible redox of NAD+/NADH derivatives by the functionalization of a gold electrode with a specially designed NAD+ derivative, and the electrochemical redox products are characterized by time-of-flight secondary ion mass spectrometry (ToF-SIMS).