Targeting NAD+ Metabolism to Enhance Radiation Therapy Responses.
Seminars in radiation oncology
confidence
Key findings
Review of NAD+ metabolism in radiation response and therapies targeting NAD+ to enhance radiation therapy; no clinical/biological endpoints reported.
View source on PubMed (PMID 30573185) ↗
- Sample size
- Not applicable
- Population
- Not specified (review article)
- Dosing
- Not applicable
- Duration
- Not applicable
- Route
- Not applicable
- Blinding
- not_reported
- Controls
- not_reported
- Drug class
- coenzyme
Full abstract
Nicotinamide adenine dinucleotide (NAD+) metabolism is integrally connected with the mechanisms of action of radiation therapy and is altered in many radiation-resistant tumors. This makes NAD+ metabolism an ideal target for therapies that increase radiation sensitivity and improve patient outcomes. This review provides an overview of NAD+ metabolism in the context of the cellular response to ionizing radiation, as well as current therapies that target NAD+ metabolism to enhance radiation therapy responses. Additionally, we summarize state-of-the-art methods for measuring, modeling, and manipulating NAD+ metabolism, which are being used to identify novel targets in the NAD+ metabolic network for therapeutic interventions in combination with radiation therapy.