NAD+animalAnimal model2020

Fatty Acid Desaturation Gets a NAD+ Reputation.

Cell metabolism

confidence

Key findings

Review article on NAD+ production by fatty acid desaturases; no clinical or biological endpoints reported.

Sample size: N/A
Population: Not applicable (review article)
Dosing: N/A
Duration: N/A
Route: N/A
Blinding: not_reported
Controls: not_reported
Drug class: coenzyme

Full abstract

delta-5 desaturase and delta-6 desaturase are enzymes known to be involved in the synthesis of highly unsaturated fatty acids. In this issue, Kim et al. (2019) show that production of NAD+ by this desaturase reaction is an adaptive response to NAD+ depletion that may regulate cellular REDOX status.

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