Aza- and Azo-Stilbenes: Bio-Isosteric Analogs of Resveratrol.
Molecules (Basel, Switzerland)
confidence
Key findings
Review of synthetic aza- and azo-stilbene analogs of resveratrol; no clinical or biological endpoints reported.
View source on PubMed (PMID 32019195) ↗
- Sample size
- N/A
- Population
- Not applicable (review of synthetic resveratrol analogs)
- Dosing
- N/A
- Duration
- N/A
- Route
- N/A
- Blinding
- not_reported
- Controls
- not_reported
- Drug class
- polyphenol
Full abstract
Several series of natural polyphenols are described for their biological and therapeutic potential. Natural stilbenoid polyphenols, such as trans-resveratrol, pterostilbene and piceatannol are well-known for their numerous biological activities. However, their moderate bio-availabilities, especially for trans-resveratrol, prompted numerous research groups to investigate innovative and relevant synthetic resveratrol derivatives. This review is focused on isosteric resveratrol analogs aza-stilbenes and azo-stilbenes in which the C=C bond between both aromatic rings was replaced with C=N or N=N bonds, respectively. In each series, synthetic ways will be displayed, and structural sights will be highlighted and compared with those of resveratrol. The biological activities of some of these molecules will be presented as well as their potential therapeutic applications. In some cases, structure-activity relationships will be discussed.