NAD metabolism in aging and cancer.
Experimental biology and medicine (Maywood, N.J.)
confidence
Key findings
Review of NAD metabolism pathways connecting energy balance, growth, genomic integrity, malignancy, and aging; no clinical/biological endpoints reported.
View source on PubMed (PMID 32500741) ↗
- Sample size
- N/A
- Population
- Not applicable (review article on NAD metabolism)
- Dosing
- N/A
- Duration
- N/A
- Route
- N/A
- Blinding
- not_reported
- Controls
- not_reported
- Drug class
- coenzyme
Full abstract
NAD is a central metabolite connecting energy balance and organismal growth with genomic integrity and function. It is involved in the development of malignancy and has a regulatory role in the aging process. These processes are mediated by a diverse series of enzymes whose common focus is either NAD's biosynthesis or its utilization as a redox cofactor or enzyme substrate. These enzymes include dehydrogenases, cyclic ADP-ribose hydrolases, mono(ADP-ribosyl)transferases, poly(ADP-ribose) polymerases, and sirtuin deacetylases. This article describes the manifold pathways that comprise NAD metabolism and promotes an increased awareness of how perturbations in these systems may be important in disease prevention and/or progression.