NAD+review2021

Location, Location, Location: Compartmentalization of NAD+ Synthesis and Functions in Mammalian Cells.

Trends in biochemical sciences

confidence

Key findings

Review of NAD+ compartmentalization in mammalian cells; no clinical or biological endpoints reported.

Sample size: N/A
Population: Mammalian cells (review)
Dosing: N/A
Duration: N/A
Route: N/A
Blinding: not_reported
Controls: not_reported
Drug class: coenzyme

Full abstract

The numerous biological roles of NAD+ are organized and coordinated via its compartmentalization within cells. The spatial and temporal partitioning of this intermediary metabolite is intrinsic to understanding the impact of NAD+ on cellular signaling and metabolism. We review evidence supporting the compartmentalization of steady-state NAD+ levels in cells, as well as how the modulation of NAD+ synthesis dynamically regulates signaling by controlling subcellular NAD+ concentrations. We further discuss potential benefits to the cell of compartmentalizing NAD+, and methods for measuring subcellular NAD+ levels.

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