NAD+animalAnimal model2021
Maestro of the SereNADe: SLC25A51 Orchestrates Mitochondrial NAD.
Trends in biochemical sciences
confidence
Key findings
SLC25A51 identified as major mitochondrial NAD+ transporter; review of NAD+ biology, no clinical/biological endpoints reported.
View source on PubMed (PMID 33618948) ↗
- Sample size
- Not reported
- Population
- Mammalian cells (in vitro)
- Dosing
- Not reported
- Duration
- Not reported
- Route
- Not reported
- Blinding
- not_reported
- Controls
- none
- Drug class
- coenzyme
Full abstract
Recently, three groups, Girardi et al., Kory et al., and Luongo et al., independently identified solute carrier (SLC) 25A51 as the long-sought, major mitochondrial NAD+ transporter in mammalian cells. These studies not only deorphan an uncharacterized transporter of the SLC25A family, but also shed light on other aspects of NAD+ biology.