Synthesis, Characterization, and Cellular Uptake of Magnesium Maltol and Ethylmaltol Complexes.
ACS omega
confidence
Key findings
Synthesis and characterization of magnesium maltol and ethylmaltol complexes; no clinical or biological endpoints reported.
View source on PubMed (PMID 34778643) ↗
- Sample size
- Not reported
- Population
- In vitro (cellular uptake study)
- Dosing
- Not reported
- Duration
- Not reported
- Route
- Not reported
- Blinding
- not_reported
- Controls
- none
- Drug class
- mineral supplement
Full abstract
Magnesium deficiency and/or deficit (hypomagnesemia, <0.75 mmol/L in the blood) has become a recognized problem in healthcare and clinical settings. Concomitantly, supplementation has become recognized as the primary means of mitigating such deficiencies. Common magnesium supplements typically suffer from shortcomings: rapid dissociation and subsequent laxation (magnesium salts: e.g., magnesium chloride), poor water solubility (magnesium oxides and hydroxides), poor characterizability (magnesium chelates), and are/or use of non-natural ligands. To this end, there is a need for the development of fully characterized, water-soluble, all-natural magnesium compounds. Herein, we discuss the synthesis, solution and solid-state characterization, aqueous solubility, and cellular uptake of magnesium complexes of maltol and ethylmaltol, ligands whose magnesium complexes have yet to be fully explored.