Graphene quantum dots an efficient nanomaterial for enhancing the photostability of trans-resveratrol in food samples.
Food chemistry
confidence
Key findings
GQDs inhibit trans- to cis-resveratrol isomerization under light, enhancing photostability and antioxidant capacity; no biological endpoints reported.
View source on PubMed (PMID 35349896) ↗
- Sample size
- Not reported
- Population
- In vitro (food samples)
- Dosing
- Not reported
- Duration
- Not reported
- Route
- Not applicable
- Blinding
- not_reported
- Controls
- none
- Drug class
- polyphenol
Full abstract
Given the health-promoting properties associated with trans-resveratrol consumption and knowing its photochemical instability, as it rapidly isomerizes to the less biologically active conformer, the photoprotective role of a carbon-based nanomaterial was investigated. The resveratrol adsorption on graphene quantum dots (GQDs), synthesized from uric acid, produces a considerable inhibition in the trans- to cis-resveratrol conversion process under light-induced radiation, conferring photostability to the bioactive. The influence of different parameters affecting the adsorption efficiency and loading capacity of resveratrol on GQDs was explored. Several characterization techniques confirmed this interaction, even proving to be non-toxic at the concentration at which the maximum inhibition of isomerization occurs. This adsorption also implies an increase in the antioxidant capacity of the polyphenol. The photoprotective effect was evaluated in food samples, resulting in a considerable slowing down of isomerization. This fact confirms the potential of GQDs to be an effective vehicle of trans-resveratrol to supplement food systems.