NAD+ and its possible role in gut microbiota: Insights on the mechanisms by which gut microbes influence host metabolism.
Animal nutrition (Zhongguo xu mu shou yi xue hui)
confidence
Key findings
Review summarizing NAD+ metabolism, host metabolism, gut microbiota-host metabolism link, and potential effects of NAD+ on microbial metabolism; no clinical/biological endpoints reported.
View source on PubMed (PMID 35949199) ↗
- Sample size
- N/A
- Population
- Not applicable (review article)
- Dosing
- N/A
- Duration
- N/A
- Route
- N/A
- Blinding
- not_reported
- Controls
- not_reported
- Drug class
- coenzyme
Full abstract
Nicotinamide adenine dinucleotide (NAD+) is an enzyme cofactor, co-substrate, and redox factor in all living cells and is necessary for maintaining cell metabolism. It has been shown that appropriate supplementation of NAD+ precursors or inhibition of NAD+-depleting enzymes can promote mitochondrial oxidative phosphorylation and improve host energy utilization efficiency. In addition, increasing evidence indicates that the gut microbiota plays a pivotal role in host metabolism. Theoretically, there should be a close correlation among NAD+, gut microbiota, and host metabolism; however, the information is limited. In this review, we summarize the metabolic process of NAD+ and its impact on host metabolism, the link between gut microbiota and host metabolism, as well as the potential effects of NAD+ on microbial metabolism, providing a new perspective on the interaction between gut microbiota and host metabolism.