NAD+observational2022
Sharing the load in NAD metabolism.
Cell host & microbe
confidence
Key findings
Isotope labeling study describing symbiotic NAD metabolism between host and gut microbiota; no clinical/biological endpoints reported.
View source on PubMed (PMID 36521437) ↗
- Sample size
- Not reported
- Population
- Host tissues and gut microbiota (in vitro isotope labeling study)
- Dosing
- Not reported
- Duration
- Not reported
- Route
- Not reported
- Blinding
- not_reported
- Controls
- none
- Drug class
- coenzyme
Full abstract
Recently in Cell Metabolism, Challapa et al. used isotope labeling to track NAD metabolism in host tissues and the gut microbiota. They describe a symbiotic relationship in which the gut microbiota uses host-derived nicotinamide to generate NAD and in return, produces nicotinic acid for host NAD biosynthesis.