Intrahypothalamic effects of oxytocin on PVN CRH neurons in response to acute stress.
Current opinion in endocrine and metabolic research
confidence
Key findings
Review of intrahypothalamic oxytocin/CRH interactions during acute stress; no clinical or biological endpoints reported.
View source on PubMed (PMID 36618014) ↗
- Sample size
- Not applicable
- Population
- Not applicable (review article)
- Dosing
- Not applicable
- Duration
- Not applicable
- Route
- Not applicable
- Blinding
- not_reported
- Controls
- not_reported
- Drug class
- stress hormone modulation
Full abstract
Much of the centrally available oxytocin (OT) is synthesized in magnocellular neurons located in the paraventricular nucleus of the hypothalamus. This same area is home to parvocellular corticotropin-releasing hormone (CRH) synthesizing neurons that regulate activation of the hypothalamic-pituitary-adrenal (HPA) axis. A large body of data indicates that complex interactions between these systems inextricably link central OT signaling with the neuroendocrine response to stress. This review focuses on a small but diverse set of cellular and synaptic mechanisms that have been proposed to underlie intrahypothalamic OT/CRF interactions during the response to acute stress.