Prebioticsreview2023

Molecular insights and therapeutic implications of nanoengineered dietary polyphenols for targeting lung cancer: part II.

Nanomedicine (London, England)

confidence

Key findings

Review of flavonoid nanoengineered systems for lung cancer; no clinical or biological endpoints reported.

Sample size: N/A
Population: Not applicable (review of flavonoid nanoengineering for lung cancer)
Dosing: N/A
Duration: N/A
Route: N/A
Blinding: not_reported
Controls: not_reported
Drug class: prebiotic

Full abstract

Flavonoids represent a major group of polyphenolic compounds. Their capacity to inhibit tumor proliferation, cell cycle, angiogenesis, migration and invasion is substantially responsible for their chemotherapeutic activity against lung cancer. However, their clinical application is limited due to poor aqueous solubility, low permeability and quick blood clearance, which leads to their low bioavailability. Nanoengineered systems such as liposomes, nanoparticles, micelles, dendrimers and nanotubes can considerably enhance the targeted action of the flavonoids with improved efficacy and pharmacokinetic properties, and flavonoids can be successfully translated from bench to bedside through various nanoengineering approaches. This review addresses the therapeutic potential of various flavonoids and highlights the cutting-edge progress in the nanoengineered systems that incorporate flavonoids for treating lung cancer.

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