Characteristics of HRT users in Japan: Evidence from the Japan Nurses' Health Study.
Maturitas
confidence
Key findings
Observational study on HRT use characteristics; no clinical or biological endpoints reported.
View source on PubMed (PMID 37105007) ↗
- Sample size
- 15,019 participants; 4886 reported menopausal transition
- Population
- Middle-aged women in Japan (Japan Nurses' Health Study cohort)
- Dosing
- Not reported
- Duration
- 10-year follow-up
- Route
- Not reported
- Blinding
- not_reported
- Controls
- none
- Drug class
- estrogen therapy
Full abstract
Little is known about what type of women use hormone replacement therapy (HRT) in Japan. Based on the Japan Nurses' Health Study (JNHS), a large population cohort study, we determined the characteristics of HRT users by comparing the characteristics of new HRT users and the characteristics of women who did not use HRT during a 10-year follow-up period. Of the 15,019 JNHS participants, 4886 women reported an experience of menopausal transition during the 10-year follow-up period. Characteristics of new HRT users. The proportion of HRT users during the 10-year period was 8.5 %. Advanced age at menopause was significantly associated with a low rate of use of HRT. Past use of oral contraceptives, dysmenorrhea with disturbance in daily life and vasomotor symptoms were significantly associated with a high rate of use of HRT. The occupations of public health nurse and midwife and a history of bilateral oophorectomy were also significantly associated with a high rate of use of HRT. We determined the characteristics of new HRT users among middle-aged women during a 10-year follow-up period. Women who had sufficient knowledge about endocrinological hormones and women who had less reluctance to visit doctors for gynecological problems were likely to use HRT.