Polydispersity of glycosaminoglycans in normal human urine.
The Tohoku journal of experimental medicine
confidence
Key findings
Analytical study characterizing polydispersity of GAGs in normal human urine; no clinical or biological endpoints reported.
View source on PubMed (PMID 6781104) ↗
- Sample size
- Not reported
- Population
- Normal human urine (analytical study)
- Dosing
- Not applicable
- Duration
- Not reported
- Route
- Not applicable
- Blinding
- not_reported
- Controls
- none
- Drug class
- glycosaminoglycan
Full abstract
To elucidate precise nature of urinary glycosaminoglycans (GAG) GAG in the acidic subfractions obtained in a previous paper (Endo et al. 1980) were quantitated by digestion with mucopolysaccharidases, nitrous acid treatment and by quantitative cellulose acetate membrane (Separax) electrophoresis. Hyaluronic acid, chondroitin sulfates and chondroitin, dermatan sulfate and dermatan, heparan sulfate, keratan sulfate, and acidic glycopeptide were found in wide distribution in these subfractions. The results suggested the presence of various degree of the depolymerization products of each GAG and of wide range of the desulfation products of each sulfated GAG. Distribution map of each GAG in the subfractions showed more detailed polydispersity of GAG in normal human urine than that reported previously.